刘勇 博士 研究员
	糖脂代谢与调控研究组组长 E-mail: liuy@@sibs.ac.cn (发邮件时请删除一个@)

个人简介：
1986、1989年分别获北京大学生物化学专业学士、硕士学位；1995年于美国Rutgers新泽西州立大学获微生物学和分子遗传学博士；1995年－2000年在美国加州大学Santa Barbara分校进行博士后研究工作。2000年-2003年于美国加州AlleCure/Mannkind免疫学生物工程公司R&D部门任Senior Scientist。2003年7月受聘于中科院上海生科院营养科学研究所。现任中科院营养与代谢重点实验室副主任，营养科学研究所所长助理。2004年入选中国科学院“百人计划”获择优支持、同时获中国科学院人教局海外人才引进专项基金。2009年获国家杰出青年科学基金和“明治乳业生命科学优秀奖”。2010年入选“上海市优秀学科带头人”。

研究领域：
糖脂代谢调控与代谢性疾病的发病机制。利用动物模型系统，通过分子生物学手段探索营养失衡、细胞应激与糖脂代谢调控发生紊乱的生理学机制关联，揭示肥胖、脂肪肝与2型糖尿病发生发展的分子基础。

研究队伍：
李文君 副研究员，副研究组长

近期论文：

1. Mao T, Shao M, Qiu Y, Huang J, Zhang Y, Song B, Wang Q, Jiang L, Liu Yi, Han JD, Cao P, Li J, Gao X, Rui L, Qi L, Li W and Liu Y. PKA Phosphorylation Couples Hepatic IRE1a to Glucagon Signaling in Glucose Metabolism. Proc. Natl. Acad. Sci. U.S.A. in press. (2011)

2. George CX, Gan Z, Liu Y, Samuel CE. Adenosine deaminases acting on RNA, RNA editing, and interferon action. J Interferon Cytokine Res. 31:99-117. (2011) (Review)

3. Huang P, Li S, Shao M, Qi Q, Zhao F, You J, Mao T, Li W, Yan Z, Liu Y. Calorie restriction and endurance exercise share potent anti-inflammatory function in adipose tissues in ameliorating diet-induced obesity and insulin resistance in mice. Nutr Metab. (Lond) 7:59. (2010)

4. Yang L, Zhao L, Gan Z, He Z, Xu J, Gao X, Wang X, Han W, Chen L, Xu T, Li W, Liu Y. Deficiency in RNA editing enzyme ADAR2 impairs regulated exocytosis. FASEB J. 24:3720-32. (2010)

5. Wang Q, Li S, Jiang L, Zhou Y, Li Z, Shao M, Li W, Liu Y. Deficiency in hepatic ATP-citrate lyase affects VLDL-triglyceride mobilization and liver fatty acid compositions of mice. J. Lipid Res. 51:2516-26. (2010)

6. You J, Yu Y, Jiang L, Li W, Yu X, Gonzalez L, Yang G, Ke Z, Li W, Li C and Liu Y. Tyr985 signaling of leptin receptor as an age/diet-dependent switch in regulation of energy balance. Mol. Cell. Biol. 30:1650-9. (2010)

7. Song W, Ren D, Li W, Jiang L, Cho KW, Huang P, Fan C, Song Y, Liu Y and Rui L. SH2B Regulation of Growth, Metabolism, and Longevity in Both Insects and Mammals. Cell Metab. 11:427-37. (2010)

8. Qiu Y, Mao T, Zhang Y, Shao M, You J, Ding Q, Chen Y, Wu D, Xie D, Lin X, Gao X, Kaufman RJ, Li W, Liu Y. A crucial role for RACK1 in regulation of glucose-stimulated IRE1alpha activation in pancreatic β-cells. Sci. Signal. 3, ra7. (2010)

9. Wang Q, Jiang L, Wang J, Li S, Yu Y, You J, Zeng R, Gao X, Rui L, Li W and Liu Y. Abrogation of hepatic ATP-citrate lyase protects against fatty liver and ameliorates hyperglycemia in leptin receptor-deficient mice. Hepatology. 49:1166-75. (2009)

10. Jiang L, Wang Q, Yu Y, Zhao F, Huang P, Zeng R, Qi RZ, Li W and Liu Y. Leptin Contributes to the Adaptive Responses of Mice to High-fat Diet Intake through Suppressing the Lipogenic Pathway. PLoS ONE. 4:e6884. (2009)

11. Yu Z, Ye X, Wang J, Qi Q, Franco OH, Rennie KL, Pan A, Li H, Liu Y, Hu FB, Lin X. Associations of physical activity with inflammatory factors, adipocytokines, and metabolic syndrome in middle-aged and older Chinese people. Circulation 119:2969-77. (2009)

12. Wu H, Wei L, Bao Y, Lu J, Huang P, Liu Y, Jia W, Xiang K. Fenofibrate reduces serum retinol-binding protein-4 by suppressing its expression in adipose tissue. Am. J. Physiol. Endocrinol. Metab. 296:E628-34. (2009)

13. Wu Y, Li H, Loos RJ, Qi Q, Hu FB, Liu Y, Lin X. Genetic variation in the RBP4 gene, plasma retinol binding protein-4 levels, and hypertriglyceridemia risk in a Chinese Han population. J. Lipid Res. 50: 1479-1486. (2009)

14. Jiang L, You J, Yu X, Gonzalez L, Yu Y, Wang Q, Yang G, Li W, Li C, Liu Y. Tyrosine-dependent and -independent actions of leptin receptor in control of energy balance and glucose homeostasis. Proc. Natl. Acad. Sci. U.S.A. 105:18619-24. (2008)

15. Wang J, Li H, Franco OH, Yu Z, Liu Y, Lin X. Association of plasma adiponectin levels with metabolic syndrome in the middle-aged and elderly Chinese. Obesity 16:172-8. (2008)

16. Sun L, Franco OH, Hu FB, Cai L, Yu Z, Li H, Ye X, Qi Q, Wang J, Pan A, Liu Y and Lin X. Ferritin concentrations, metabolic syndrome, and type 2 diabetes in middle-aged and elderly Chinese. J. Clin. Endocrinol. Metab. 93:4690-6. (2008)

17. Qi Q, Yu Z, Ye X, Zhao F, Huang P, Hu F, Franco OH, Wang J, Li H, Liu Y, Lin X. Elevated retinol-binding protein 4 levels are associated with metabolic syndrome in Chinese people. J. Clin. Endocr. Metab. 92:4827-34. (2007)

18. Li H, Wu Y, Loos R, Frank H, Liu Y, Wang J, Yu Z, Lin X. Variants in FTO gene are not associated with obesity in a Chinese Han population. Diabetes 57:264-8. (2007)

19. Ye X, Yu Z, Li H, Franco OH, Liu Y, Lin X. Distributions of c-reactive protein and its association with metabolic syndrome in middle-aged and older Chinese people. J. Am. Coll. Cardiol. 49:1798-805. (2007)

20. Gan Z, Zhao L, Yang L, Huang P, Zhao F, Li W, Liu Y. RNA editing by ADAR2 is metabolically regulated in pancreatic islets and beta-cells. J. Biol. Chem. 281:33386-94. (2006)

申请专利：

1. 刘勇, 李文君, 王珏, 王琼. ACL在筛选防治肥胖相关代谢疾病的药物中的应用. (专利申请号200810037556.2)

2. 刘勇, 林旭, 赵峰, 戚琦彬, 李文君. 人视黄醇结合蛋白-4在代谢异常的检测中的应用. (专利申请号200710040180.6)