Yan Chen Ph.D., Professor
	Laboratory of Signal Transduction and Nutrition-related Diseases E-mail: ychen3@@sibs.ac.cn

Education Background & Academic Experience:
Dr. Chen got a Bachelor degree from the Medical School at West China University of Medical Sciences in 1983; got a Master degree from Department of Pediatrics, West China University of Medical Sciences in 1986; and got a Ph.D. from Department of Medical and Molecular Genetics from Indiana University School of Medicine in 1994. Dr. Chen did his postdoctoral training in University of California at San Diego and Salk Institute. Dr. Chen had been working in Indiana University School of Medicine as an Assistant Professor and Associate Professor. Dr. Chen joined the faculty of Institute for Nutritional Sciences at Shanghai, China in 2004.

Research Interests:
The research interests of our laboratory are to apply tools of molecular biology, cell biology and animal models to understand the molecular mechanisms, signal transduction, gene regulation, and functional roles in human diseases in the areas of type 2 diabetes, cancer and embryonic development. Our current research is focused on understanding the molecular mechanisms underlying adiponectin and apolipoprotein in type 2 diabetes and insulin resistance, regulation of MAPK signaling pathway and its function in tumorigenesis, and TGF-beta related proteins in early development and human diseases.

Research Team:
Zhenzhen Wang, Co-Principal Investigator

Selected Publications:

1. Jin T, Ding Q, Huang H, Xu D, Jiang Y, Zhou B, Li Z, Jiang X, He J, Liu W, Zhang Y, Pan Y, Wang Z, Thomas WG, Chen Y. PAQR10 and PAQR11 mediate Ras signaling in the Golgi apparatus. Cell Res. 2012 Apr;22(4):661-76.

2. Wang Z, Yang L, Jiang YH, Ling ZQ, Li ZG, Cheng Y, Huang H, Wang LD, Yi P, Wang ZZ, Yan XQ, Chen Y. High Fat Diet Induces Formation of Spontaneous Liposarcoma in Mouse Adipose Tissue with Overexpression of Interleukin 22. PLoS One. 2011 Aug; 6(8): e23737.

3. Ruan X, Li Z, Zhang Y, Yang L, Pan Y, Wang Z, Feng GS and Chen Y. Apolipoprotein A-I possesses an anti-obesity effect associated with increase of energy expenditure and up-regulation of UCP1 in brown fat. J Cell Mol Med. 2011 Apr; 15(4):763-72.

4. Zhu L, Wang L, Wang X, Luo X, Yang L, Zhang R, Yin H, Xie D, Pan Y and Chen Y. Hepatic deletion of smad7 in mouse leads to spontaneous liver dysfunction and aggravates alcoholic liver injury. PLoS One. 2011 Feb 28; 6(2):e17415.

5. Jiang, Y., Xie, X., Li, Z., Wang, W., Zhang, Y., Ling, Z., Pan, Y., Wang. Z., and Chen, Y. Functional cooperation of RKTG with p53 in tumorigenesis and epithelial-mesenchymal transition. Cancer Res. 2011; 71(8):2959-68.

6. Luo, X., Zhang, Y., Ruan, X., Jiang, X., Zhu, L., Wang, X., Ding, Q., Liu, W., Pan, Y., Wang, Z., and Chen, Y. A fasting-induced protein phosphatase 1 regulatory subunit contributes to postprandial blood glucose homeostasis via regulation on hepatic glycogenesis. Diabetes. 2011; 60(5):1435-45.

7. Luo, X., Ding, Q., Wang, M., Li, Z., Mao, K., Sun, B., Zang, Y.Q., and Chen, Y. In vivo disruption of TGF-β signaling by Smad7 in airway epithelium alleviates allergic asthma but aggravates lung carcinogenesis. PLoS ONE. 2010; 5(4): e10149.

8. Zhang, Y., Jiang X., Qin X., Ye D., Yi Z., Liu M., Bai O., Liu W., Xie X., Wang, Z., Fang J., Chen Y. RKTG inhibits angiogenesis by suppressing MAPK-mediated autocrine VEGF signaling and is downregulated in clear-cell renal cell carcinoma. Oncogene. 2010 Sep; 29(39):5404-15.

9. Yang, L., Zhang, Y., Wang, L., Fan, F., Zhu, L., Li, Z., Ruan, X., Huang, H., Wang, Z., Huang, Z., Huang, Y., Yan, X., and Chen, Y. Amelioration of high fat diet induced liver lipogenesis and hepatic steatosis by interleukin-22. Journal of Hepatology. 2010; 53:339-47.

10. Jiang, Y., Xie, X., Zhang, Y., Luo, X., Wang, X., Fan, F., Zheng, D., Wang, Z., and Chen, Y. Regulation of G protein signaling by RKTG via sequestrating Gbetagamma subunit to Golgi apparatus. Molecular and Cellular Biology. 2010; 30(1):78-90.

11. Ding, Q., Wang, Z., and Chen, Y. Endocytosis of adiponectin receptor 1 through a clathrin- and Rab5-dependent pathway. Cell Res. 2009; 19(3):317-27.

12. Chen, Q., Chen, H., Zheng, D., Kuang, C., Fang, H., Zou, B., Zhu, W., Bu, G., Jin, T., Wang, Z., Zhang, X., Chen, J., Field, L. J., Rubart, M., Shou, W., and Chen, Y. Smad7 is required for the development and function of heart. Journal of Biological Chemistry. 2009; 284, 292-300.

13. Yang, L., Wu, Y., Li, H., Yu, Z., Li, X., Liu, Y., Lin, X., and Chen, Y. Potential association of INSIG2 rs7566605 polymorphism with body weight in a Chinese subpopulation. European Journal of Human Genetics. 2008; 16, 759-61.

14. Fan, F., Feng, L., He, J., Wang, X., Jiang, X., Zhang, Y., Wang, Z. and Chen, Y. RKTG sequesters B-Raf to the Golgi apparatus and inhibits the proliferation and tumorigenicity of human malignant melanoma cells. Carcinogenesis. 2008;. 29, 1157-63.

15. Luo, X., Feng, L., Jiang, X., Xiao, F., Wang, Z, Feng, G.S. and Chen, Y. Characterization of the topology and functional domains of RKTG. Biochemical Journal. 2008; 414, 399-406.

16. Xie, X., Zhang, Y., Jiang, Y., Liu, W., Ma, H., Wang, Z. and Chen, Y. Suppressive function of RKTG on chemical carcinogen- induced skin carcinogenesis in mouse. Carcinogenesis. 2008; 29, 1632-8.

17. Han R, Lai R, Ding Q, Wang Z, Luo X, Zhang Y, Cui G, He J, Liu W and Chen, Y. Apolipoprotein A-I stimulates AMP-activated protein kinase and improves glucose metabolism. Diabetologia. 2007; 50:1960-1968.

18. Feng L, Xie X, Ding Q, Luo X, He J, Fan F, Liu W, Wang Z, Chen, Y. Spatial regulation of Raf kinase signaling by RKTG. Proc Natl Acad Sci U S A. 2007; 104:14348-53.