Shengzhong Duan Ph.D., Professor
	Laboratory of Nuclear Receptors in Metabolism and Diseases E-mail: szduan@@sibs.ac.cn

Education Background & Academic Experience:
Dr. Duan received his Bachelor of Clinical Medicine in 1994 and Master of Medicine (Biochemistry) in 1997 from Hubei Medical University (now Wuhan University School of Medicine). Then he worked as a lecturer at Capital Medical University (Beijing) from 1997 to 2000. He received his PhD in Pharmacology from University of Michigan, Ann Arbor in 2006, and finished his postdoctoral training in departments of Molecular & Integrative Physiology and Internal Medicine at University of Michigan Medical School from 2006 to 2010. He joined Institute for Nutritional Sciences, Chinese Academy of Sciences in 2010.

Research Interests:
We currently focus on peroxisome proliferator activated receptor γ (PPARγ) and mineralocorticoid receptor (MR). The major diseases we study are diabetes, obesity, cardiovascular disease, and tumor. Our methodology includes transgenic mouse models, surgical mouse models, molecular biology, and cellular biology. We use these approaches to investigate the function of nuclear receptors in metabolism, as well as molecular mechanisms and therapies of these diseases.

Selected Publications:

1. Duan SZ* and Mortensen RM. A New Connection: Myeloid Mineralocorticoid Receptor and Cardiovascular Disease. NAJMS. 2010; 3(4):167-170. (*corresponding author)

2. Frieler RA, Meng H, Duan SZ, Berger S, Schütz G, Wang MM, Mortensen RM. Myeloid-Specific Deletion of the Mineralocorticoid Receptor Reduces Infarct Volume and Alters Inflammation During Focal Cerebral Ischemia. Stroke. 2010. In press.

3. Usher MG*, Duan SZ^*,ζ, Ivashchenko CY, Frieler RA, Berger S, Schütz G, Lumeng C, Mortensen RM^ζ. Myeloid mineralocorticoid receptor controls macrophage polarization and cardiovascular hypertrophy and remodeling in mice. J Clin Invest. 2010 Sep; 120(9):3350-3364. (*Co-first author; ^ζCo-corresponding author)

4. Duan SZ, Usher MG, Foley EL 4th, Milstone DS, Brosius FC 3rd, Mortensen RM. Sex dimorphic actions of rosiglitazone in generalised peroxisome proliferator-activated receptor-gamma (PPAR-gamma)-deficient mice. Diabetologia. 2010 Jul; 53(7):1493-505.

5. Zhang J, Ouyang J, Wang G, Xia ZY, Duan SZ, Wu Y. Role of PKCζ translocation in the development of type 2 diabetes in rats following continuous glucose infusion. Diabetes Metab Res Rev. 2010 Jan; 26(1): 59-70.

6. Duan SZ, Usher MG, Mortensen RM. PPARs: the vasculature, inflammation and hypertension. Curr Opin Nephrol Hypertens. 2009 Mar; 18(2):128-133.

7. Gupta D, Jetton TL, Mortensen RM, Duan SZ, Peshavaria M, Leahy JL. In vivo and in vitro studies of a functional peroxisome proliferator-activated receptor gamma response element in the mouse PDX-1 promoter. J Biol Chem. 2008; 283(47):32462-70.

8. Duan SZ, Ivashchenko CY, Usher MG, Mortensen RM. PPAR-g in the cardiovascular system. PPAR Res. 2008: 745804.

9. Duan SZ, Usher MG, Mortensen RM. PPAR-g mediated effects in the vasculature. Circ Res. 2008; 102(3): 283-294.

10. Ye CP, Duan SZ**, Milstone DS, Mortensen RM. Go controls the hyperpolarization-activated current, If in ES cell-derived cardiocytes. Am J Physiol Heart and Circulatory Physiol. 2008; 294(2):H979-985. (**Co-first author)

11. Duan SZ, Ivashchenko CY, Whitesall SE, D’Alecy LG, Mortensen RM. Direct monitoring pressure overload predicts cardiac hypertrophy in mice. Physiological Measurement. 2007; 28(11): 1329-1339.

12. Ivashchenko CY, Duan SZ, Usher MG, Mortensen RM. PPAR-g knockout in pancreatic epithelial cells abolishes the inhibitory effect of Rosiglitazone on cerulein-induced acute pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2007; 293(1): G319-326.

13. Duan SZ, Christe M, Milstone DS, Mortensen RM. Go but not Gi2 or Gi3 is required for muscarinic regulation of heart rate and heart rate variability in mice. Biochem Biophys Res Commun. 2007 May; 357(1): 139-143.

14. Duan SZ, Ivashchenko CY, Whitesall SE, D'Alecy LG, Duquaine DC, Brosius FC, Gonzalez FJ, Vinson C, Pierre MA, Milstone DS, Mortensen RM. Hypotension, lipodystrophy, and insulin resistance in generalized PPAR-g-deficient mice rescued from embryonic lethality. J Clin Invest. 2007; 117(3): 812-822.