Feifan Guo Ph.D., Professor
	Laboratory of genetic and nutritional regulation of metabolic Diseases E-mail: ffguo@@sibs.ac.cn

Education Background & Academic Experience:
Dr. Feifan Guo is a principal investigator and head of the Laboratory of genetic and nutritional regulation of metabolic Diseases at INS. She earned her medical degree from Dalian Medical University in 1992 and obtained her Ph.D. at Neuroscience from the University of Tokyo in 2001. After that, she did postdoc training at Department of Psychiatry, University of Minnesota (2001 - 2002), and Division of Endocrinology, Beth Israel Deaconess Medical Center at Harvard Medical School (2002 - 2005). She worked as a Research Assistant Professor at Department of Biology, the Pennsylvania State University before joining INS in September 2007.

Research Interests:
The long term goal of our research interest is to understand the cellular and molecular mechanisms underlying genetic and nutritional regulation of metabolic diseases including obesity, diabetes, and fatty liver. This will be achieved by using molecular and cellular biology techniques in animal models and cell lines. Currently, our lab research interest focuses on elucidating the mechanisms of central and peripheral regulation of altered lipid metabolism under leucine deprivation. These studies will certainly provide important evidence for the better understanding, and hopefully lead to the possible nutritional prevention or treatment of certain metabolic diseases, such as obesity, diabetes and fatty liver.

Research Team:

Selected Publications:

1. Du Y, Meng Q, Zhang Q, Guo F*. Isoleucine or valine deprivation stimulates fat loss via increasing energy expenditure and regulating lipid metabolism in WAT. Amino Acids. 2011 Oct 21. [Epub ahead of print]

2. Cheng Y#, Zhang Q# (co-author), Meng Q, Xia T, Huang Z, Wang C, Liu B, Chen S, Xiao F, Du Y, and Guo F*. Leucine Deprivation Stimulates Fat Loss via Increasing CRH Expression in The Hypothalamus and Activating The Sympathetic Nervous System. Molecular Endocrinology. 2011, 25(9):1624-1635.

3. Li H, Meng Q, Xiao F, Chen S, Yu J, Wang C, and Guo F*. ATF4 deficiency protects mice from high-carbohydrate diet-induced liver steatosis. Biochemical Journal. 2011, 438(2):283-289.

4. Xiao F, Huang Z, Li H, Yu J, Wang C, Chen S, Meng Q, Cheng Y, Gao X, Li J, Liu Y, and Guo F*. Leucine Deprivation Increases Hepatic Insulin Sensitivity Via GCN2/mTOR/S6K1 and AMPK Pathways. Diabetes. 2011, 60: 746-756.

5. Zhang Q, Li H and Guo F*. Amygdala, an important regulator for food intake (Invited Review). Frontiers in Biology. 2011, 6: 82-85.

6. Cheng Y#, Meng Q# (co-author), Wang C, Li H, Huang Z, Chen S, Xiao F, Guo F*. Leucine deprivation decreases fat mass by stimulation of lipolysis in WAT and upregulation of UCP1 in BAT. Diabetes. 2010, 59: 17-25.

7. Wang C, Huang Z, Du Y, Cheng Y, Chen S and Guo F*. ATF4 regulates lipid metabolism and thermogenesis. Cell Research. 2010, 20:174-184.

8. Guo F, Cavener D. The GCN2 eIF2α Kinase Regulates Fatty-Acid Homeostasis in the Liver during Deprivation of an Essential Amino Acid. Cell Metabolism. 2007, 5:103-114.

9. Ebihara T, Guo F, Zhang L, Kim JY, Saffen D. Muscarinic acetylcholine receptors stimulate Ca2+ influx in PC12D cells predominantly via activation of Ca2+ store-operated channels. The Journal of Biochemistry. 2006, 139: 449-458.

10. Zhang L, Guo F, Kim J, Saffen D. Muscarinic Acetylcholine Receptors Activate TRPC6 Channels in PC12D Cells via Ca2+ Store–Independent Mechanisms. The Journal of Biochemistry. 2006, 139: 459-470.