Lin He Ph.D., Professor (Part-time)
	Members of CAS Laboratory of Nutrigenomics E-mail: lhe@@sibs.ac.cn

Education Background & Academic Experience:
Ph.D. in Microbiology/Biochemistry, Department of Biology, University of Paisley.
Postdoctoral Researcher, Institute of Molecular and Cell Biology, University of Edinburgh.
Senior Researcher Fellow, MRC (Medical Research Council) Human Genetic Unit, University of Edinburgh.
Principal Investigator, Shanghai Research Center of Life Sciences, China Academy of Sciences.
Principal Investigator, Shanghai Institute of Physiology, China Academy of Sciences.
Director, Human Neuropsychiatric Genetics Group (NHGG) of Shanghai JiaoTong University & China Academy of Sciences.
Director, Bio-X Center of Life Sciences, Shanghai JiaoTong University.
Dean, Institutes of Biomedical Sciences, Fudan University.
Principal Investigator, Institute for Nutritional Sciences, Shanghai Institute for Biological Sciences, China Academy of Sciences.

Research Interests:
Neuropsychiatry related disorders; Nutrition associated diseases; Pharmcogenomics; Bioinformatics.

Research Team:
Sheng Li, Co-Principal Investigator
He Xu, Associate Professor

Selected Publications:

1. Ning M, Zhang Z, Chen Z, Zhao T, Zhang D, Zhou D, Li W, Liu Y, Yang Y, Li S, He L. Genetic evidence that vascular dementia is related to Alzheimer's disease: genetic association between tau polymorphism and vascular dementia in the Chinese population. Age Ageing. 2011 Jan;40(1):125-8. Epub 2010 Nov 2.

2. Zhao T, Liu Z, Zhang D, Liu Y, Yang Y, Zhou D, Chen Z, Yu L, Zhang Z, Feng G, He L, Xu H. The ENPP1 K121Q polymorphism is not associated with type 2 diabetes or obesity in the Chinese Han population. J Hum Genet. 2011 Jan;56(1):12-6. Epub 2010 Oct 28.

3. Shen Q, Zhang J, Wang Y, Liu B, Li X, Zhao Q, Chen S, Ji J, Yang F, Wan C, Gao L, Xu Y, Feng G, He L, He G. No association between the KCNH1, KCNJ10 and KCNN3 genes and schizophrenia in the Han Chinese population. Neurosci Lett. 2011 Jan 3;487(1):61-5. Epub 2010 Oct 7.

4. Ning M, Yang Y, Zhang Z, Chen Z, Zhao T, Zhang D, Zhou D, Xu J, Liu Z, Wang Y, Liu Y, Zhao X, Li W, Li S, He L. Amyloid-beta-Related Genes SORL1 and ACE are Genetically Associated With Risk for Late-onset Alzheimer Disease in the Chinese Population. Alzheimer Dis Assoc Disord. 2010 Jul 9. [Epub ahead of print]

5. Liu Y, Zhou D, Zhang Z, Song Y, Zhang D, Zhao T, Chen Z, Sun Y, Zhang D, Yang Y, Xing Q, Zhao X, Xu H, He L. Effects of Genetic Variants on Lipid Parameters and Dyslipidemia in Chinese population. J Lipid Res. 2011 Feb;52(2):354-60. Epub 2010 Dec 12.

6. Xu J, Liu Y, Wang P, Li S, Wang Y, Li J, Zhou D, Chen Z, Zhao T, Wang T, Xu H, Yang Y, Feng G, He L, Yu L. Positive Association Between the Brain-Derived Neurotrophic Factor (BDNF) Gene and Bipolar Disorder in the Han Chinese Population. AM J MED GENET B. 2010 Jan 5;153B(1):275-9.

7. Gao B, Hu J, Stricker S, Cheung M, Ma G, Law KF, Witte F, Briscoe J, Mundlos S, He L, Cheah KS, Chan D. A mutation in Ihh that causes digit abnormalities alters its signalling capacity and range. Nature. 2009 Apr 30;458(7242):1196-200.

8. Zhao T, Liu Y, Wang P, Li S, Zhou D, Zhang D, Chen Z, Wang T, Xu H, Feng G, He L, Yu L. Positive association between the PDLIM5 gene and bipolar disorder in the Chinese Han population. J Psychiatry Neurosci. 2009 May;34(3):199-204.

9. Liu Y, Yu L, Zhang D, Chen Z, Zhou DZ, Zhao T, Li S, Wang T, Hu X, Feng GY, Zhang ZF, He L, Xu H. Positive association between variations in CDKAL1 and type 2 diabetes in HanChinese individuals. Diabetologia. 2008 Nov; 51(11):2134-7.

10. Shen Q, Li X, Qiu Y, Su M, Liu Y, Li H, Wang X, Zou X, Yan C, Yu L, Li S, WanC, He L, Jia W. Metabonomic and metallomic profiling in the amniotic fluid of malnourishedpregnant rats. J Proteome Res. 2008 May;7(5):2151-7.

11. Xuan J, Zhao X, He G, Yu L, Wang L, Tang W, Li X, Gu N, Feng G, Xing Q, He L. Effects of the Dopamine D(3) Receptor (DRD3) Gene Polymorphisms on Risperidone Response: A Pharmacogenetic Study. Neuropsychopharmacology. 2008 Jan;33(2):305-11.

12. Zhao X, Qin S, Shi Y, Zhang A, Zhang J, Bian L, Wan C, Feng G, Gu N, Zhang G, He G, He L. Systematic study of association of four GABAergic genes: glutamic acid decarboxylase 1 gene, glutamic acid decarboxylase 2 gene, GABA(B) receptor 1 gene and GABA(A) receptor subunit beta2 gene, with schizophrenia using a universal DNA microarray. Schizophr Res. 2007 Jul;93(1-3):374-84.

13. Xu MQ, St Clair D, Ott J, Feng GY, He L. Brain-derived neurotrophic factor gene C-270T and Val66Met functional polymorphisms and risk of schizophrenia: a moderate-scale population-based study and meta-analysis. Schizophr Res. 2007 Mar;91(1-3):6-13.

14. Wang L, Yu L, He G, Zhang J, Zhang AP, Du J, Tang RQ, Zhao XZ, Ma J, Xuan JK, Xiao Y, Gu NF, Feng GY, Xu MQ, Xing QH, He L. Response of risperidone treatment may be associated with polymorphisms of HTT gene in Chinese schizophrenia patients. Neurosci Lett. 2007 Feb 27;414(1):1-4.

15. Li D, He L. G72/G30 genes and schizophrenia: a systematic meta-analysis of association studies. Genetics. 2007 Feb;175(2):917-22.

16. Zhang AP, Yu J, Liu JX, Zhang HY, Du YY, Zhu JD, He G, Li XW, Gu NF, Feng GY, He L. The DNA methylation profile within the 5'-regulatory region of DRD2 in discordant sib pairs with schizophrenia. Schizophr Res. 2007 Feb;90(1-3):97-103.

17. Zhao X, Tang R, Gao B, Shi Y, Zhou J, Guo S, Zhang J, Wang Y, Tang W, Meng J, Li S, Wang H, Ma G, Lin C, Xiao Y, Feng G, Lin Z, Zhu S, Xing Y, Sang H, St Clair D, He L. Functional variants in the promoter region of Chitinase 3-like 1 (CHI3L1) and susceptibility to schizophrenia. Am J Hum Genet. 2007 Jan;80(1):12-8.

18. Li D, He L. Meta-analysis supports association between serotonin transporter (5-HTT) and suicidal behavior. Mol Psychiatry. 2007 Jan;12(1):47-54.