Yi Liu Ph.D., Professor
	Laboratory of Molecular pathogenesis of type 2 diabetes and obesity E-mail: liuyi@@sibs.ac.cn

Education Background & Academic Experience:
Dr. Liu obtained his Bachelor degree from the Department of Genetics at Fudan University in 1997 and Ph.D. degree from the Division of Biomedical Sciences, University of California at Riverside in 2004. Dr. Liu did his postdoctoral training at University of California, Riverside and Salk Institute. Dr. Liu joined Institute of Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences at the end of 2009.

Research Interests:
By combing animal model, structural, molecular and cellular biology, we investigate the underlying molecular basis of the pathogenesis and pathophysiology of type 2 diabetes and other obesity-caused diseases. We currently focus on understanding the transcriptional, posttranscriptional and posttranslational regulation of genes involved in glucose and lipid metabolism in liver and exploring their roles in the pathophysiology of type 2 diabetes.

Selected Publications:

1. Eric E Zhang*, Yi Liu*, Renaud Dentin, Pagkapol Y Pongsawakul, Andrew C Liu, Tsuyoshi Hirota, Dmitri A Nusinow, Xiujie Sun, Severine Landais, Yuzo Kodama, David A Brenner, Marc Montminy, Steve A Kay. Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis. (2010) Nature Medicine. 16: 1152-1156. doi:10.1038/nm.2214.

2. Liu Y*, Dentin R*, Chen D*, Hedrick S, Ravnskjaer K, Schenk S, Milne J, Meyers DJ, Cole P, Yates JR 3rd, Olefsky J, Guarente L, Montminy M. A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange. (2008) Nature, 456, 269-73.

3. Dentin R*, Liu Y*, Koo SH, edrick S, Vargas T, Heredia J, Yates JR 3rd, Montminy M. Insulin Modulates Gluconeogenesis via Inhibition of the Coactivator TORC2 (2007) Nature, 449(7160):366-9.
   * These authors contributed equally to the manuscript and should be considered co-first authors.