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Principal Investigator
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Fudi Wang Ph.D., Professor
Laboratory of Mineral Molecular Nutrition

E-mail: wangfd@@sibs.ac.cn

Education Background & Academic Experience:
Dr. Wang earned his Bachelor's degree from the School of Public Health at HeBei Medical University in 1992, obtained his Master's degree from the School of Medicine at Shanghai Tongji University in 1995, and received his Ph.D. from the Department of Public Health at Second Military Medical University in 1998. He first worked as an Assistant Professor and then Associate Professor and Department Chair in the Faculty of Naval Medicine, Second Military Medical University from 1998 to 2002. Dr. Wang completed postdoctoral training in the Department of Nutritional Sciences and Biochemistry, University of Missouri-Columbia from 2002 to 2004. He served as an Instructor at Harvard Medical School and Children's Hospital Boston from 2004 to 2008. Dr. Wang joined the faculty of the Institute for Nutritional Sciences at Shanghai, China in 2008.

Research Interests:
My laboratory is interested in investigating molecular mechanisms of zinc and iron metabolism by applying molecular, cell biological, biochemical, and genetic approaches. Our current studies focus on ZIP zinc transporters, erythroid iron metabolism, macrophages iron recycling and the novel iron modifier proteins.

Research Team:

Selected Publications:

  1. Zhang Z, Zhang F, Guo X, An P, Tao Y, Wang F*. Ferroportin1 in hepatocytes and macrophages is required for the efficient mobilization of body iron stores. Hepatology. 2012 Apr. DOI: 10.1002/hep.25746

  2. An P, Wu Q, Wang H, Guan Y, Mu M, Liao Y, Zhou D, Song P, Wang C, Meng L, Man Q, Li L, Zhang J, Wang F*. TMPRSS6, but not TF, TFR2, or BMP2 Variants are Associated with Increased Risk of Iron Deficiency Anemia. Hum Mol Genet. 2012 May 1;21(9):2124-31.

  3. Gan W, Guan Y, Wu Q, An P, Zhu J, Lu L, Jing L, Yu Y, Ruan S, Xie D, Makrides M, Gibson RA,Anderson GJ, Li H*, Lin X* and Wang F*. Association of TMPRSS6 polymorphisms with ferritin, hemoglobin and type 2 diabetes risk in a Chinese Han population. Am J Clin Nutr. 2012 Mar;95(3):626-32.

  4. Anderson GJ and Wang F. Essential but toxic: Controlling the flux of iron in the body. Clin Exp Pharmacol Physiol, 2011, in press. (Invited review)

  5. Zhang ZZ, Zhang F, An P, Guo X, Shen Y, Tao Y, Wu Q, Zhang Y, Yu Y, Ning B, Nie G, Knutson MD, Anderson GJ and Wang F*. Ferroportin1 deficiency in mouse macrophages impairs iron homeostasis and inflammatory responses. Blood, 2011 Aug 18;118(7):1912-1922.

  6. Ba Q, Hao M, Huang H, Hou J, Ge S, Zhang Z, Yin J, Jiang H, Wang F, Liu H and Wang H. Iron Deprivation Caused by a Novel Iron Chelator, Thiosemicarbazone-24, Suppresses Hepatocellular Carcinoma in vitro and in Mouse Models. Clin Cancer Res. 2011 Dec 15;17(24):7625-33. Epub 2011 Nov 3.

  7. Zhang Y, Shen Y, Yan X and Wang F*. Molecular Mechanisms of Mammalian Iron Homeostasis. Chinese Journal of Cell Biology, 2011 Nov, 33(11):1179-1190. (Invited review)

  8. Shen YY and Wang F*. New insights of ferritin synthesis, secretion, uptake and functions in iron homeostasis. Chinese Journal of Cell Biology. 2011, 33(4):336 (Commentary)

  9. Yu Y, Wang F*. Zinc Transporters: Critical regulators of Zinc Homeostasis. Chinese Journal of Cell Biology, 2010, 32(2): 176-188 (Invited review)

  10. Mills Eric, Dong XP, Wang F and Xu HX. Mechanisms of Brain Iron Transport: Insight into Neurodegeneration and CNS Disorders. Future Medical Chemistry. 2010 Jan;2(1):51-64 ( Invited review)

  11. Feng YX, Zhao JS, Li JJ, Wang T, Cheng SQ, Yuan Y, Wang F, Wang XF, Xie D. Liver cancer: EphrinA2 promotes tumorigenicity through Rac1/Akt/NF-kappaB signaling pathway. Hepatology. 2010 Feb; 51(2):535-44.

  12. Chen P, Hu P, Xie D, Qin Y, Wang F, Wang H. Meta-analysis of vitamin D, calcium and the prevention of breast cancer. Breast Cancer Res Treat. 2010 Jun;121(2):469-77.

  13. Guo L, Lichten LA, Ryu MS, Liuzzi JP, Wang F and Cousins RJ. STAT5-glucocorticoid receptor interaction and MTF-1 regulate the expression of ZnT2 (Slc30a2) in pancreatic acinar cells. Proc Natl Acad Sci USA. 2010 Feb 16;107(7):2818-23.

  14. Dong XP, Cheng XP, Mills E, Delling M, Wang F and Xu H. The Type IV Mucolipidosis-Associated Protein TRPML1 is an Endo-lysosomal Iron Release Channel. Nature. 2008 Oct 16;455(7215):992-996.

  15. Wang F, Paradkar PN, Custodio AO, Ward DM, Fleming MD, Campagna D, Roberts KA, Boyartchuk V, Dietrich WF, Kaplan J, and Andrews NC. Genetic variation in Mon1a protein trafficking modifies macrophage iron loading in mice. Nature Genetics, 2007:39(8), 1025-1032.

  16. Liu S, Suragani RNVS, Wang F, Han A, Zhao W, Fleming MD, Andrews NC and Chen JJ. Deficiency of Heme-Regulated eIF2¦Á Kinase Attenuates Macrophage Maturation Inflammatory Response and Iron Homeostasis. The Journal of Clinical Investigation, 2007:117(11):3296-305.

  17. Wang F, Lothrop AP, James NG, Griffiths TAM, Lambert LA, Leverence R, Kaltashov IA, Andrews NC, Macgillivray RTA and Mason AB. A novel murine protein with no effect on iron homeostasis is homologous to transferrin and is the putative inhibitor of carbonic anhydrase. Biochemical Journal, 2007;406(1):85-95.

  18. Mao XQ, Kim BE, Wang F, Eide DJ and Petris MJ. A histidine-rich cluster mediates the ubiquitination and degradation of the human zinc transporter, hZIP4, and protects against zinc cytotoxicity. The Journal of Biological Chemistry, 2007;282(10):6992-7000.

  19. Lim JE, Jin O, Bennett C, Morgan K, Wang F, Trenor III CC, Gilliland DG, Fleming MD and Andrews NC. A mutation in Sec15l1 causes anemia in hemoglobin deficit (hbd) mice. Nature Genetics, 2005;37: 1270-1273.

  20. Mathews W, Wang F, Eide DJ and Van Doren M. (2005) Drosophila fear of intimacy encodes a ZIP family zinc transporter functionally related to mammalian ZIP proteins. The Journal of Biological Chemistry, 280(1):787-95.

  21. Wang F, Kim BE, Dufner-Beattie J, Andrews GK, Petris MJ and Eide DJ. (2004) Acrodermatitis enteropathica mutations affect transport activity, localization, and zinc-responsive trafficking of the mouse Zip4 zinc transporter. Human Molecular Genetics, 13(5):563-571.

  22. Wang F, Dufner-Beattie J, Kim BE, Petris MJ, Andrews GK and Eide DJ. (2004) Zinc-stimulated endocytosis controls activity of the mouse ZIP1 and ZIP3 zinc uptake transporters. The Journal of Biological Chemistry, 279(23):24631-24639.

  23. Wang F, Kim BE, Petris MJ and Eide DJ. (2004) The mammalian ZIP5 protein is a zinc transporter that localizes to the basolateral surface of polarized cells. The Journal of Biological Chemistry, 279(49):51433-52441.

  24. Ellis CD, Wang F, MacDiarmid CW, Clark S, Lyons T and Eide DJ. (2004) Zinc and Msc2 zinc transporter protein are required for endoplasmic reticulum function. The Journal of Cell Biology, 166(3):325-335.

  25. Kim BE, Wang F, Dufner-Beattie J, Andrews GK, Eide DJ and Petris MJ. (2004) Zn2+-stimulated endocytosis of the mZIP4 zinc transporter regulates its location at the plasma. The Journal of Biological Chemistry, 279(6):4523-4530.

  26. Dufner-Beattie J, Wang F, Kou YM, Gitschier J, Eide DJ and Andrews GK. (2003) The Acrodermatitis Enteropathica gene ZIP4 encodes a tissue-specific, zinc-regulated, zinc transporter in mice. The Journal of Biological Chemistry, 278(35): 33474-33481.

  27. Dufner-Beattie J, Langmade SJ, Wang F, Eide DJ and Andrews GK. (2003) Structure, function, and regulation of a subfamily of mouse zinc transporter genes. The Journal of Biological Chemistry, 278(50): 50142-50150.

  28. Wang F, Bian W, Kong, L., Zhao F, Guo J, Jing, N. (2001) Maternal Zinc Deficiency Impairs Brain Nestin Expression in Prenatal and Postnatal Mice. Cell Research, 2001,11(2): 135-141.

  29. Long J, Zhang Y, Shen H, Qin H, Chen J, Wang F and Wang H. (2004) Scanning Differential Expression Genes In The Brain Of Offsprings With Zinc Deficiency During Pregnancy. Acta Nutrimenta Sinic, 26 (2)89-93 (Chinese)

  30. Long J, Zhang Y, Shen H, Qin H and Wang F.(2004) Effects of different zinc intake on mRNA expression of DMT1 in weaned mice. Chinese Journal of Public Health, 20(7):772-774(Chinese)

  31. Zhang Y, Long J, Shen H, Qin H, Chen J and Wang F. (2004) Effects of different zinc intakes on brain and testis expression of zinc transporter 3 mRNA in weaned mice. Academic Journal Second Military Medical University, 25 (8) 838-841(Chinese)

  32. Qin H., Shen H, Wang F, et al. (2004) Expression of metallothioneins on zinc exposure in rat hippocampal neurons. Journal of Hygiene Research, 33(5):562-4(Chinese)

  33. Qin H, Shen H, Wang F. (2004) Effect of zinc on the expression of zinc transporter 1 and metallothionein mRNA in primary culture rat hippocampal cells. Academic Journal of Second Military University, 25(1)12-14(Chinese)

  34. Long J, Wang F, Chen J and Shen H. (2002) Cloning of ZnT3 cDNA and expression of ZnT3 mRNA in mice. Journal of Hygiene Research, 31(2):103-105(Chinese)

  35. Wang F, Zhao F, Guo J and Jing N. (2000) Effect of Zinc on Glial Fibrillary Acidic Protein (GFAP) Expression in the Central Nervous System of Developing Mice. Acta Nutrimenta Sinica, 22 (1): 9-13 (Chinese)

  36. Wang F, Zhao F and Guo J. (2000) Effects of Zinc Deficiency During Pregnancy and Lactation of Maternal Mice on Bcl-2 mRNA Expression in Brain of Offsprings. Acta Nutrimenta Sinica 22 (2): 105-108(Chinese)

  37. Wang F, Zhao F, Guo J and Jing N. (2000) Effects of Dietary Zinc on ¦Á-tubulin and ¦Â-tubulin Expression in the Central Nervous System of Mice. Acta Nutrimenta Sinic, 22(3): 193-197 (Chinese)

  38. Wang F, Zhao F, Guo J and Jing N. (1999) Effect of Dietary Zinc on Microtuble- Associated Protein 2 Expression in Brain of Mice. Acta Physiologica Sinica, 51 (5): 495-500(Chinese)

  39. He H, Wang F and Cai M. (1999) Effect of Antioxidant Vitamins on Proliferation and Apoptosis of Aortic Endothelial Cells. Acta Nutrimenta Sinica, 21 (4): 444-449(Chinese)

  40. He H, Wang F, Cai M. (1999) Effect of Antioxidant Vitamins on Lipid Peroxide Injury of Aortic Endothelial Cells Induced by Oxidatively Modified Low-density Lipoprotein in Vitro. Journal of Hygiene Research, 28 (2): 97-99(Chinese)

  41. He H, Wang F, Cai M. (1999) Effect of Antioxidant Nutrients on Lipid Peroxide Injury of Aortic Endothelial Cells. Acta Nutrimenta Sinica 1999, 21 (2): 230-231(Chinese)

  42. Wang F, Zhao F, Jing N and Guo J. (1998) Effect of Zinc Deficiency During Pregnancy and Lactation of Maternal Mice on Learning Ability and Hippocampal Long-term Potentiation of Offspring. China Journal of Neuroscience, 14 (1): 20-23(Chinese)

  43. Wang F, Cai M and Zhu S. (1997) Preventive Effect of Selenium and/or Vitamin on Endothelial Cells Damage in Experimental Hyperlipidemic Rats. Acta Nutrimenta Sinica, 19 (2): 163-166(Chinese)

  44. Wang F, Cai M and Zhu S. (1997) Effects of Selenium and/or Vitamin on Serum Lipids and Lipoperoxides in Experimental Hyperlipidemic Rats. Acta Nutrimenta Sinica, 19 (1): 16-22 (Chinese)

  45. Wang F, He H and Li X. (1997) The Preventive Effect of Magnesium on Experimental atherosclerosis. Academic Journal of Military Medical University, 18 (2): 128-130(Chinese)

  46. Wang F, Chen B, Ding Y, Zhu S and Cai M. (1997) Effect of Composite Hawthorn Fruit Liquor on Serum Lipids and Lipoperoxides in Rats. China Journal of Public Health, 16(1): 42-43(Chinese)

  47. Wang F, Chen B, Zhu S and Cai M. (1997) Effect of Composite Hawthorn Fruit Liquor on Plasma Prostacyclin Thromboxane in Rats. China Journal of Gerontology, 17(2): 108-110 (Chinese)

  48. Wang F, He H, Zhu S, and Cai M (1996) Effects of Oenotheria Binnis Seed Oil on Lipoperoxides, Plasma Thromboxane, Prostacyclin and Endothelin in Experimental Hyperlipidemic Rats. Journal of Hygiene Research, 25 (5): 312-315 (Chinese)
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