Hui Wang Ph.D., Professor
	Laboratory of Molecular Pharmacology and Toxicology E-mail: huiwang@@sibs.ac.cn

Education Background & Academic Experience:
Dr. Wang is a Principal Investigator, Professor, and the Head of the Laboratory of Molecular Pharmacology and Toxicology at INS. She obtained her Ph. D. from Tianjin Medical University / University of Alabama at Birmingham (a joint PhD program) in 1999. After graduation, she continued her research at University of Alabama at Birmingham as a post-doctoral researcher. In 2001, she joined the faculty in the Department of Pharmacology and Toxicology, Division of Clinical Pharmacology as an Instructor and was promoted to Assistant Professor in 2002. She joined INS in October 2005.

Research Interests:
1) Drug discovery and molecular pharmacology and toxicology
2) Nutrition & environment and disease prevention
3) Applied Nutriceutical Sciences and Food safety (including fast detection approach and the action mechanism of noxious substances in foods)

Research Team:

Selected Publications:

1. Ba Q, Hao M, Huang H, Hou J, Ge S, Zhang Z, Yin J, Chu R, Jiang H, Wang F, Chen K, Liu H and Wang H*. Iron deprivation suppresses hepatocellular carcinoma growth in experimental studies. Clin Cancer Res. 2011 Dec 15;17(24):7625-33. (*Corresponding author)

2. Chen T, Xu Y, Guo H, Liu Y, Hu P, Yang X, Li X, Ge S, Velu S, Nadkarni D, Wang W, Zhang R and Wang H*. Experimental therapy of ovarian cancer with synthetic Makaluvamine Analog: In vitro and in vivo anticancer activity and molecular mechanisms of action. PLoS ONE. 2011;6(6):e20729. (*Corresponding author)

3. Duan J, Ba Q, Wang Z, Hao M, Hu P, Li X, Zhang D, Zhang R and Wang H*. Knockdown of Ribosomal Protein S7 Causes Developmental Abnormalities via p53 Dependent and Independent Pathways in Zebrafish. Int J Biochem Cell Biol. 2011 Aug;43(8):1218-27. (*Corresponding author)

4. Guo D, Chen T, Ye D, Xu j, Jiang H, Chen K, Wang H* and Liu H. Cell-permeable Iminocoumarine-based Fluorescent Dyes for Mitochondria. Org Lett. 2011 Jun 3;13(11):2884-7. (*Corresponding author)

5. Li M, Zhou Y, Chen P, Yang H, Yuan X, Tajima K, Cao J and Wang H*. Genetic Variants on Chromosome 8q24 and Colorectal Neoplasia Risk: A Case-control Study in China and a Meta-analysis of the Published Literature. PLoS ONE. 2011 Mar; 6(3):e18251. (*Corresponding author)

6. Hao M, Wang W, Zhao Y, Zhang R and Wang H*. Pharmacokinetics and tissue distribution of 25-hydroxyprotopanaxadiol, an anti-cancer compound isolated from Panax ginseng, in athymic mice bearing xenografts of human pancreatic tumors. Eur J Drug Metab Pharmacokinet. 2011 Jan;35(3-4):109-13. (*Corresponding author)

7. Feng Y, Wang T, Deng Y, Yang P, Li J, Guan D, Yao F, Zhu Y, Qin Y, Wang H, Li N, Wu M, Wang H, Wang X, Cheng S and Xie D. Sorafenib suppresses postsurgical recurrence and metastasis of hepatocellular carcinoma in an orthotopic mouse model. Hepatology. 2011 Feb;53(2):483-92.

8. Hao M, Ba Q, Yin J, Li J, Zhao Y and Wang H*. Deglycosylated ginsenosides are more potent inducers of CYP1A1, CYP1A2 and CYP3A4 expression in HepG2 cells than glycosylated ginsenosides. Drug Metabolism and Pharmacokinetics. 2011;26(2):201-5. (*Corresponding author)

9. Tang H, Pang S, Wang M, Xiao X, Rong Y, Wang H, Zang YQ. TLR4 activation is required for IL-17-induced multiple tissue inflammation and wasting in mice. J Immunol. 2010 Aug 15;185(4):2563-9.

10. Liang J, Chen P, Hu Z, Shen H, Wang F, Chen L, Li M, Tang J, Wang H* and Shen H. Genetic variants in trinucleotide repeat-containing 9 (TNRC9) are associated with risk of estrogen receptor positive breast cancer in a Chinese population. Breast Cancer Res Treat. 2010 Nov;124(1):237-41. (*Corresponding author)

11. Feng Y, Ding X, Chen T, Chen L, Liu F, Jia X, Luo X, Shen X, Chen K, Jiang H, Wang H*, Liu H, Liu D. Design, synthesis and interaction study of quinazoline-2(1H)-thione derivatives as potential novel Bcl-xL Inhibitors. J Med Chem. 2010 May 13;53(9):3465-79. (*Corresponding author)

12. Lin S, Chen T, Liu XH, Shen YH, Li HL, Shan L, Liu RH, Xu XK, Zhang WD, Wang H*. Iridoids and Lignans from Valeriana jatamansi. J Nat Prod. 2010 Apr 23;73(4):632-8. (*Corresponding author)

13. Chen P, Hu P, Xie D, Qin Y, Wang F, and Wang H*. Meta-analysis of Vitamin D, Calcium and the Prevention of Breast Cancer. Breast Cancer Res Treat. 2010 Jun;121(2):469-77. (*Corresponding author)

14. Chen T, Li M, Zhang R, and Wang H*. Dihydroartemisinin Induces Apoptosis and Sensitizes Human Ovarian Cancer Cells to Carboplatin Therapy. J Cell Mol Med. 2009 Jul;13(7):1358-70. (*Corresponding author)

15. Lin S, Shen YH, Li HL, Yang XW, Chen T, Lu LH, Huang ZS, Liu RH, Xu XK, Zhang WD, Wang H*. Acylated iridoids with cytotoxicity from Valeriana jatamansi. J Nat Prod. 2009 Apr;72(4):650-5. (*Corresponding author)

16. Chen D, Zhang J, Li M, Rayburn ER, Wang H, Zhang R. RYBP stabilizes p53 by modulating MDM2. EMBO Rep. 2009 Feb;10(2):166-72.

17. Liang J, Chen P, Hu Z, Zhou X, Chen L, Li M, Wang Y, Tang J, Wang H* and Shen H. Genetic variants in fibroblast growth factor receptor 2 (FGFR2) contribute to susceptibility of breast cancer in Chinese women. Carcinogenesis. 2008 Dec;29(12):2341-6. (*Corresponding author)

18. Chen P, Liang J, Wang Z, Zhou X, Chen L, Li M, Xie D, Hu Z, Shen H, and Wang H*. Association of Common PALB2 Polymorphisms with Breast Cancer Risk: a Case-Control Study. Clin Cancer Res. 2008. Sep 15; 14 (8): 5931-37. (* Corresponding author)

19. Hou J, Wang D, Zhang R, and Wang H*. Experimental Therapy of Hepatoma with Artemisinin and Its Derivatives: In vitro and In vivo Activity, Chemosensitization, and Mechanisms of Action. Clin Cancer Res. 2008 Sep 1; 14(17):5519-30. (* Corresponding author)

20. Hao M, Zhao Y, Chen P, Huang H, Liu H, Zhang R, and Wang H*. Structure-Activity Relationship and Substrate-dependent Phenomena in Effects of Ginsenosides on Activities of Drug-metabolizing P450 Isozymes. PLoS ONE. 2008 Jul 16;3(7):e2697. (* Corresponding author)

21. Wang W, Wang H*, Rayburn ER, Zhao Y, Hill DL, Zhang R. 20(S)-25-methoxyl-dammarane-3β, 12β, 20-triol, a novel natural product for prostate cancer: activity in vitro and in vivo and mechanisms of action. Br J Cancer. 2008 Feb 26;98(4):792-802. (*Co-first and Corresponding author)

22. Wang W, Rayburn ER, HaoM, Zhao Y, Hill DL, Zhang R, Wang H*. Experimental Therapy of Prostate Cancer with Novel Natural Product Anti-cancer Ginsenosides. Prostate. 2008 Mar 6;68(8):809-819 .(*Corresponding author)

23. Chen D, Zhang Z, Li M, Wang W, Li Y, Rayburn ER, Hill DL, Wang H*, Zhang R. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. Oncogene. 2007 Aug 2;26(35):5029-37. (*Corresponding author)

24. Rayburn E, Wang W, Zhang R., Wang H*. Experimental therapy for colon cancer: anti-cancer effects of TLR9 agonism, combination with other therapeutic modalities, and dependence upon p53. Intl J Oncol. 2007 Jun;30(6):1511-9. (*Corresponding author)

25. Wang W, Zhao Y, Rayburn E, Hill DL, Wang H, Zhang R. In vitro anti-cancer activity and structure-activity relationships of natural products isolated from fruits of Panax ginseng. Cancer Chem Pharm. 2007 Apr;59(5):589-601.

26. Wang H*, Wang Y, Rayburn ER, Hill DL, Rinehart JJ, Zhang R. Dexamethasone as a chemosensitizer for breast cancer chemotherapy: Potentiation of the antitumor activity of adriamycin, modulation of cytokine expression, and pharmacokinetics. Intl J Oncol. 2007 Apr;30(4):947-53. (*Corresponding author)

27. Wang H, Li M, Lin W, Wang W, Zhang Z, Rayburn E, Lu J, Chen D, Yue X, Shen F, Jiang F, He J, Wei W, Zeng X. Zhang R. Extracellular activity of cAMP-dependent protein kinase (ECPKA) as a biomarker for human cancer detection: distribution characteristics in a normal population and cancer patients. Can Epidem Biomarker Prev. 2007 Apr;16(4):789-95.

28. Li M, Zhang Z, Hill DL, Wang H, Zhang R. Curcumin, a dietary component, has anti-cancer, chemosensitization and radiosensitization effects by down-regulating the MDM2 oncogene through the PI3 kinase/mTOR/ETS2 pathway. Cancer Res. 2007 Mar 1;67(5):1988-96.

29. Zhao Y, Wang W, Rayburn E, Hill DL, Wang H, Zhang R. Isolation, Structural Determination, and Evaluation of the Biological Activity of 20(S)-25-methoxyl-dammarane-3β, 12β, 20-triol [20(S)-25-OCH3-PPD], a Novel Natural Product from Panax notoginseng. Med Chem. 2007;3:51-60.