Song Xiang Ph.D., Professor
	Laboratory of Structural Biological Studies of Nutrition Related Processes E-mail: sxiang@@sibs.ac.cn

Education Background & Academic Experience:
Dr. Song Xiang received his Bachelor's and master's degrees in physics from Fudan University and the City College of New York, City University in 1997 and 1999, before switching fields to biology. In 2004 he received his PhD in Biophysics from the State University of New York at Stony Brook. He did his postdoctoral training at Columbia University, from 2004 to 2009. He joined the Institute of Nutritional Sciences in 2009.

Research Interests:
We are interested in understanding how proteins and other important bio-macromolecules function. With structural, biochemical, biophysical and other techniques, we study the structure and function relationship of bio-macromolecules. Our current research interests include: 1) structural and functional studies of cellular metabolism and its regulation; 2) structural and functional studies of the cellular DNA damage responses.

Research Team:

Selected Publications:

1. Fan C, Chou CY, Tong L, Xiang S*. Crystal structure of urea carboxylase provides insights into the carboxyltransfer reaction. J Biol Chem. 2012 Mar 16;287(12):9389-98. (* Corresponding author)

2. Chang JH, Xiang S, Tong L. 5'-3' Exoribonucleases. Book chapter, Ribonucleases. Nucleic Acids and Molecular Biology, Springer. 2011; 26:167-192.

3. Chang JH*, Xiang S*, Xiang K, Manley JL, Tong L. Structural and biochemical studies of the 5'→3' exoribonuclease Xrn1. Nat Struct Mol Biol. 2011 Mar;18(3):270-6. (*-equal contribution)

4. Lasso G, Yu LP, Gil D, Xiang S, Tong L, Valle M, Cryo-EM Analysis Reveals New Insights into the Mechanism of Action of Pyruvate Carboxylase. Structure. 2010 Oct 13; 18(10): 1300-10.

5. Xiang K, Nagaike T*, Xiang S*, Kilic T, Beh MM, Manley JL, Tong L, Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex., Nature. 2010 Oct 7; 467(7316): 729-33. (*-equal contribution)

6. Jiao X, Xiang S, Oh C, Martin CE, Tong L, Kiledjian M, Identification of a quality-control mechanism for mRNA 5'-end capping. Nature. 2010 Sep 30; 467(7315): 608-11.

7. Xiang S, Callaghan MM, Watson KG, Tong L. A different mechanism for the inhibition of the carboxyltransferase domain of acetyl-coenzyme A carboxylase by tepraloxydim. Proc Natl Acad Sci U S A. 2009 Dec; 106 (49): 20723-27.

8. Sinturel F, Pellegrini O, Xiang S, Tong L, Condon C, Bénard L, Real-time fluorescence detection of exoribonucleases. RNA. 2009 Nov; 15(11): 2057-62.

9. Yu LP, Xiang S, Lasso G, Gil D, Valle M, Tong L, A symmetrical tetramer for S. aureus pyruvate carboxylase in complex with coenzyme A. Structure. 2009 Jun 10; 17(6): 823-32.

10. Xiang S, Cooper-Morgan A, Jiao X, Kiledjian M, Manley JL, Tong L, Structure and function of the 5’®3’ exoribonuclease Rat1 and its activating partner Rai1. Nature. 2009 Apr 9; 458(7239): 784-8.

11. Xiang S, Usunow G, Lange G, Busch M, Tong L. 1-deoxy-D-xylulose 5-phosphate synthase (DXS), a crucial enzyme for isoprenoids biosynthesis. Book chapter, T.J. Bach Ed. (in press)

12. Xiang S, Tong L. Crystal structures of human and Staphylococcus aureus pyruvate carboxylase and molecular insights into the carboxyltransfer reaction. Nat Struct Mol Biol. 2008 Mar; 15(3): 295-302.

13. Khan JA*, Xiang S*, Tong L. Crystal structure of human nicotinamide riboside kinase. Structure. 2007 Aug; 15(8): 1005-13. (*-equal contribution authors)

14. Xiang S, Usunow G, Lange G, Busch M, Tong L. Crystal structure of 1-deoxy-D-xylulose 5-phosphate synthase, a crucial enzyme for isoprenoids biosynthesis. J Biol Chem. 2007 Jan 26; 282(4): 2676-82.

15. Nichols JD, Xiang S, Schindelin H, Rajagopalan KV. Mutational analysis of Escherichia coli MoeA: two functional activities map to the active site cleft. Biochemistry. 2007 Jan 9; 46(1): 78-86.