Lixin Zhan Ph.D., Professor
	Laboratory of cell polarity & cancer metabolism E-mail: lxzhan@@sibs.ac.cn

Education Background & Academic Experience:
Dr. Zhan earned a Bachelor of medicine from the Medical School at Zhejiang University in 1996; earned her Medical Doctor degree from Second Military Medical University in 2003. From 2004 to 2010, she did her postdoctoral training in Cold Spring Harbor Laboratory. Dr. Zhan joined the faculty of Institute for Nutritional Sciences at Shanghai, China in 2010.

Research Interests:
Disruption of cell polarity is an important hallmark of cancer. The role polarity proteins play during tumorigenesis is poorly understood. Using cell culture studies and mouse tumor models, we will identify novel polarity pathways play in normal cell architecture and tissue morphogenesis. Through the molecular analysis of aberrant genetic and epigenetic pathways in epithelia cancer, we want to characterize the molecular basis of cell architecture during tumor initiation and identify potential diagnosis marker or drug targets.

Selected Publications:

1. Zhan L, Rosenberg A, Bergami KC ,Yu M , Xuan Z , Jaffe A.B, Allred C, Muthuswamy SK. Deregulation of Scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma. Cell, 2008 Nov; 135(5):865-878.

2. Zhan L, Xiang B, Muthuswamy SK. Controlled activation of ErbB1/ErbB2 heterodimers promote invasion of three-dimensional organized epithelia in an ErbB1-dependent manner: implications for progression of ErbB2-overexpressing tumors. Cancer Research, 2006 Mar; 66(10): 5201-8.