Bin Zhou M.D., Ph.D., Professor
	Laboratory of Heart Development and Regeneration E-mail: zhoubin@@sibs.ac.cn

Education Background & Academic Experience:
Dr. Zhou obtained his Bachelor degree from Zhe Jiang University School of Medicine in 2002, and received Ph.D. degree from Chinese Academy of Medical Sciences and Peking Union Medical College in 2006. From 2006-2010, Dr. Zhou had postdoctoral training at Harvard Medical School and Children’s Hospital Boston, and served as instructor and research associate from 2009 to 2010. Dr. Zhou joined the Institute for Nutritional Sciences in 2010 as professor and group leader.

Research Interests:
During embryonic development, normal heart formation is regulated by many signaling pathways that orchestrate the heart morphogenesis and accompanying coronary vasculature. In some adult cardiovascular diseases such as coronary artery disease like atherosclerosis or ischemic cardiomyopathy, many embryonic cellular process and signaling pathways are recapitulated and involved in the pathogenesis of CVD. The major goal of this lab is to find the role of some key transcription factors in CVD and to dissect their mechanisms by employing the genetic mouse model, molecular and cell biology. We are also interested in reprogramming fibroblasts into cardiomyocytes to provide new ways for heart regeneration. We aim to find new cellular sources and molecular target for therapeutic use for CVD in future.

Research Team:

Recent publications (2006-2012):

1. von Gise A, Lin Z, Schlegelmilch K, Honor LB, Pan GM, Buck JN, Ma Q, Ishiwata T, Zhou B, Camargo FD, Pu WT YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy. Proc Natl Acad Sci U S A 2012; 109: 2394-2399.

2. Huang ZP, Seok HY, Zhou B, Chen J, Chen JF, Tao Y, Pu WT, Wang DZ CIP, a Cardiac Isl1-Interacting Protein, Represses Cardiomyocyte Hypertrophy. Circ Res 2012; Feb 16. [Epub ahead of print].

3. Chong JJ, Chandrakanthan V, Xaymardan M, Asli NS, Li J, Ahmed I, Heffernan C, Menon MK, Scarlett CJ, Rashidianfar A, Biben C, Zoellner H, Colvin EK, Pimanda JE, Biankin AV, Zhou B, Pu WT, Prall OW, Harvey RP Adult Cardiac-Resident MSC-like Stem Cells with a Proepicardial Origin. Cell Stem Cell 2011; 9: 527-540.

4. Asahina K, Zhou B, Pu WT, Tsukamoto H Septum transversum-derived mesothelium gives rise to hepatic stellate cells and perivascular mesenchymal cells in developing mouse liver. Hepatology 2011; 53: 983-995.

5. Zhou B, Pu WT Epicardial epithelial to mesenchymal transition in injured heart. J Cell Mol Med 2011.

6. Guo C, Sun Y, Zhou B, Adam RM, Li X, Pu WT, Morrow BE, Moon A, Li X A Tbx1-Six1/Eya1-Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesis. J Clin Invest 2011; 121: 1585-1595.

7. Zhou B, Honor LB, He H, Ma Q, Oh JH, Butterfield C, Lin RZ, Melero-Martin JM, Dolmatova E, Duffy HS, Gise A, Zhou P, Hu YW, Wang G, Zhang B, Wang L, Hall JL, Moses MA, McGowan FX, Pu WT Adult mouse epicardium modulates myocardial injury by secreting paracrine factors. J Clin Invest 2011; 121: 1894-1904.

8. Zhou B, Honor LB, Ma Q, Oh JH, Lin RZ, Melero-Martin JM, von Gise A, Zhou P, Hu T, He L, Wu KH, Zhang H, Zhang Y, Pu WT Thymosin beta 4 treatment after myocardial infarction does not reprogram epicardial cells into cardiomyocytes. J Mol Cell Cardiol 2011.

9. Smart N, Bollini S, Dube KN, Vieira JM, Zhou B, Davidson S, Yellon D, Riegler J, Price AN, Lythgoe MF, Pu WT, Riley PR De novo cardiomyocytes from within the activated adult heart after injury. Nature 2011; 474: 640-644.

10. Zhou B, von Gise A, Ma Q, Hu YW, Pu WT Genetic fate mapping demonstrates contribution of epicardium-derived cells to the annulus fibrosis of the mammalian heart. Dev Biol 2010; 338: 251-261.

11. Zhou B, Ma Q, Kong SW, Hu Y, Campbell PH, McGowan FX, Ackerman KG, Wu B, Zhou B, Tevosian SG, Pu WT Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart. J Clin Invest 2009; 119: 1462-1476.

12. Zhou B, Ma Q, Rajagopal S, Wu SM, Domian I, Rivera-Feliciano J, Jiang D, von Gise A, Ikeda S, Chien KR, Pu WT Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart. Nature 2008; 454: 109-113.

13. Mellgren AM, Smith CL, Olsen GS, Eskiocak B, Zhou B, Kazi MN, Ruiz FR, Pu WT, Tallquist MD Platelet-derived growth factor receptor beta signaling is required for efficient epicardial cell migration and development of two distinct coronary vascular smooth muscle cell populations. Circ Res 2008; 103: 1393-1401.

14. Zhou B, Ma FX, Liu PX, Fang ZH, Wang SL, Han ZB, Poon MC, Han ZC Impaired therapeutic vasculogenesis by transplantation of OxLDL-treated endothelial progenitor cells. J Lipid Res 2007; 48: 518-527.

15. Ma FX, Zhou B, Chen Z, Ren Q, Lu SH, Sawamura T, Han ZC Oxidized low density lipoprotein impairs endothelial progenitor cells by regulation of endothelial nitric oxide synthase. J Lipid Res 2006; 47: 1227-1237.

16. Zhou B, Huang P, Han ZC Autologous transplantation of granulocyte colony-stimulating factor- mobilized peripheral blood mononuclear cells improves critical limb ischemia in diabetes. Diabetes Care 2006; 29: 478-9; author reply 479-80.

17. Zhou B, Bi YY, Han ZB, Ren H, Fang ZH, Yu XF, Poon MC, Han ZC G-CSF-mobilized peripheral blood mononuclear cells from diabetic patients augment neovascularization in ischemic limbs but with impaired capability. J Thromb Haemost 2006; 4: 993-1002.