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Principal Investigator
 
Huiyong Yin Ph.D., Professor
Laboratory of Fatty Acid Metabolism in Human Nutrition and Related Diseases

E-mail: hyyin@sibs.ac.cn (delete one @ to send email)

Education Background & Academic Experience:
Dr. Huiyong Yin graduated from Tongji University with a B.S. in Chemistry in 1992. In 1995 he received his M.S. degree from Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences (CAS). After receiving his Ph.D. in the Department of Chemistry at Vanderbilt University in 2002, he joined the Division of Clinical Pharmacology at Vanderbilt School of Medicine as a research instructor and was promoted to research assistant professor in 2005 and research associate professor in 2009 in the Departments of Medicine, Pharmacology and Chemistry. He was the director of Drug Metabolism and Pharmacokinetics (DMPK) analysis for the Vanderbilt Program of Drug Discovery from 2007 to 2009. He has published around 70 peer-reviewed papers and was the PI and Co-investigator on multiple NIH grants including RO1 and PO1. He was the recipient of President¨s Graduate Award of CAS (1995), Warren Graduate Fellowship Award in the Department of Chemistry at Vanderbilt University (2000), Travel Award (2004) and Young Investigator Award (2005) from The Society of Free Radical Biology and Medicine, Best Research Paper Award in the Division of Clinical Pharmacology at Vanderbilt University (2004). In 2011 Dr. Yin joined the faculty of Institute for Nutritional Science, Shanghai Institute of Biological Sciences, CAS.

Research Interests:
The major research interests in our laboratory are (1) to apply tools of chemistry, molecular/cell biology, and animal models to study free radical mechanism of lipid oxidation and its role in human nutrition and diseases; (2) to develop mass spectrometry techniques including lipidomics, metabolomics, and proteomics to study lipid metabolism; (3) to explore nutritional intervention to prevent some nutrition-related human diseases.

Research Team:

Selected Publications:

  1. Huiyong Yin, Aur└lia Vergeade, Qiong Shi, William E. Zackert, Katherine Gruenberg, Taneem Amin, Tina S. Masterson, Sandra S. Zinkel , John A. Oates , Olivier Boutaud, L. Jackson Roberts, II. Acetaminophen Inhibits Cytochrome c Redox Cycling Induced Cardiolipin Oxidation. Biochem Biophys Res Commun. 2012 Jun 29;423(2):224-8.
  2. Huiyong Yin*, Mingjiang Zhu. Free Radical Oxidation of Cardiolipin: Chemical Mechanisms, Detection, and Implication in Apoptosis, Mitochondrial Dysfunction, and Human Diseases. Free Radic Res. 2012 Aug;46(8):959-74.
  3. Huiyong Yin, Libin Xu, and Ned A Porter. Free Radical Lipid Peroxidation: Mechanisms and Analysis. Chem. Rev. 2011, 111(10), 5944-5972.
  4. Wei Liu, Claus Schneider, Alan Brash, and Ned A Porter, Huiyong Yin*. Novel Chemical Mechanism Of 4-Hydroxynonenal (4-HNE) Formation: Cross-Chain Peroxyl Radical Addition And Decomposition In Phospholipids. Free Radic. Biol. Med., 2011. 50(1), 166-178.
  5. Huiyong Yin*, Wei Liu, Kasia Goleniewsk, Ned A. Porter, Jason D. Morrow, Ryszard Dworski, R. Stokes Peebles, Jr. Dietary Supplementation of w-3 Fatty Acid-Containing Fish Oil Enhances Inflammatory Response in a Mouse Model of Ovalbumin-Induced Allergic Lung Inflammation. Free Radic. Biol. Med. 2009, 47, 622-628.
  6. Huiyong Yin*, Todd A. Davis, and Ned A. Porter. Simultaneous Analysis of Multiple Lipid Oxidation Products in vivo by Liquid Chromatographic-Mass Spectrometry (LC-MS). Methods Mol. Biol., 2009, 375-386.
  7. Ming-Zhi Zhang, Jie Xu, Bing Yao, Huiyong Yin, Qiuyin Cai, Martha J. Shrubsole, Xiwu Chen, Valentina Kon, Wei Zheng, Ambra Pozzi, Raymond C. Harris. Inhibition of 11β hydroxysteroid dehydrogenase-2 selectively blocks the tumor cyclooxygenase-2 pathway and suppresses colon carcinogenesis. J. Clin. Invest., 2009, 119, 876-885.
  8. Huiyong Yin*, Brian E. Cox, Ned A. Porter, Jason D. Morrow. Identification of Intact Oxidation Products of Glycerophospholipids Using Negative Ion Electrospray Iontrap Mass Spectrometry. J. Mass. Spectrom., 2009, 44, 672-680.
  9. Ginger L. Milne, Huiyong Yin, and Jason D. Morrow. Human Biochemistry of the Isoprostane Pathways. J. Biol. Chem., 2008, 283, 15533-15537.

 
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