Research
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Key Lab
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Yan Chen

Ph.D., Professor
Principal Investigator, Associate Director


Email: ychen3@sibs.ac.cn

        Dr. Chen got a Bachelor degree from the Medical School at West China University of Medical Sciences in 1983; got a Master degree from Department of Pediatrics, West China University of Medical Sciences in 1986; and got a Ph.D. from Department of Medical and Molecular Genetics from Indiana University School of Medicine in 1994. Dr. Chen did his postdoctoral training in University of California at San Diego and Salk Institute. Dr. Chen had been working in Indiana University School of Medicine as an Assistant Professor and Associate Professor. Dr. Chen joined the faculty of Institute for Nutritional Sciences at Shanghai, China in 2004.

RESEARCH INTERESTS:
        The research interests of our laboratory are to apply tools of molecular biology, cell biology and animal models to understand the molecular mechanisms, signal transduction, gene regulation, and functional roles in human diseases in the areas of type 2 diabetes, cancer and embryonic development. Our current research is focused on understanding the molecular mechanisms underlying adiponectin and apolipoprotein in type 2 diabetes and insulin resistance, regulation of MAPK signaling pathway and its function in tumorigenesis, and TGF-beta related proteins in early development and human diseases.

SELECTED PUBLICATIONS:

  1. Ding Q, Wang Z, Chen, Y. Endocytosis of adiponectin receptor 1 through a clathrin- and Rab5-dependent pathway. Cell Research 2009 Mar;19(3):317-27.

  2. He J, Sun X, Qian KQ, Wang Z, Chen, Y. Protection of cerulein-induced pancreatic fibrosis by pancreas-specific expression of Smad7. Biochim Biophys Acta 2009 Jan;1792(1):56-60.

  3. Chen Q, Chen H, Zheng D, Kuang C, Fang H, Zou B, Zhu W, Bu G, Jin T, Wang Z, Zhang X, Chen J, Field LJ, Rubart M, Shou W, Chen Y. Smad7 is required for the development and function of the heart. J Biol Chem. 2009 Jan 2;284(1):292-300.

  4. Sun X, He J, Mao C, Han R, Wang Z, Liu Y, Chen Y. Negative regulation of adiponectin receptor 1 promoter by insulin via a repressive nuclear inhibitory protein element. FEBS Lett. 2008 Sep 19. [Epub ahead of print]

  5. Xie X, Zhang Y, Jiang Y, Liu W, Ma H, Wang Z, Chen Y. Suppressive function of RKTG on chemical carcinogen-induced skin carcinogenesis in mouse. Carcinogenesis. 2008 Aug;29(8):1632-8.

RESEARCH TEAM:
Zhenzhen Wang, Co-Principal Investigator